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XXXXX的原因是：
官方的解释是：
这是堵孔的警告提示。
出现于WBC和RBC，其相关分类参数均出现XXXXX。
官方处理办法：冲击微孔 ，清洗计数池。
官方分析：
真正的微孔堵塞，冲击微孔和清洗计数池无疑是有效的，手工用注射器从后池推空气，可以看到前池气泡连续密集，即可以排除真正的堵孔。
1、计数电压的变异系数影响。在Voltages/Sensors Screen屏幕中，有这么两个参数，WAV VAR和RAV VAR，这两个参数分别表示WBC的计数电压和RBC的计数电压，这个电压直接显示在屏幕上，当他们的变异系数为0时，计数结果通过，当变异系数等于1时，计数结果不被认可。WAV的变异系数小于5%，大于2%的时候，WBC相关结果用*号表示。
WAV的CV变异系数等于或者超过5%时，报XXXXX错误，就是堵孔。
RAV的CV变异系数等于或者超过6%时，报XXXXX错误，就是堵孔。
这一点跟 ABBOTT的CD1200的报警提示原理非常相似。那么这个变异系数的差别是怎么产生的呢？大家都知道，当小孔畅通，前后池都有液体（无论是稀释液还是标本混合物）的情况下，小孔两端的电压（并非理论电压，液体导电性能会降低很多）都是恒定的，细胞的大小虽然有所不同，产生的脉冲也有所不同，但总体来说不会引发电压的剧烈波动，这里的波动是指1%以上的CV变化，产生这样的波动原因有以下几点：
1）标本在计数池内的混匀不好，血细胞凝聚，溶血剂的溶血效果不好，红细胞碎片粘连，血小板凝聚，干扰物的存在，例如棉絮。
2）恒流源不稳定，这就直接是主板的问题了；还有就是主板的电容不好，同样是主板问题。
3）气泡干扰的存在，气泡肉眼可见哪怕是再密集的，远远大于细胞本身，所产生的电阻导致的压降也很大。气泡产生的原因除了管道松脱，还有就是清洗剂的问题，稀释液和溶血剂不好也会造成此类影响。Coulter的试剂从未听说有质量问题，因此在处理这类故障的时候，更换原厂试剂可以提高检查速度。
2、脉冲宽度的影响，WPWV/RPWV VAR分别表示WBC和RBC的脉冲宽度，当WPWV/RPWV VAR的CV变异系数为0时，计数结果通过，当WPWV/RPWV VAR变异系数等于1时，结果不被认可，在相应的项目上出现*，WPWV的变异系数超过12%，RPWV的变异系数超过5%，就是报XXXXX,堵孔。当WBC计数总数小于1.7，RBC计数总数小于0.2，即便是WPWV/RPWV VAR变异系数超过规定值，也不会报堵孔（这是软件判读时的计算基数问题，基数过小结果也就不超标了）。那么什么原因会导致WPWV/RPWV VAR变异系数的超标呢？除了上面1的原因，就是电路调整的问题，厂家都会提供相应的乳胶颗粒调整。
3、AVR VAR，这是一个计数小孔电压的比率。
4、AVR AVG 是通过RAV/WAV的电压数值得来的，并且显示的是最后一个结果的值。
5、RM是上一次样本测试时的AVR平均数。
6、DELTA AVR是AVR AVG 和AVR RM的比较。
DELTA AVR大于5%(0.05),报RBCXXXXX，堵孔。DELTA AVR大于-2小于等于-5，WBC结果出现*，不可靠标志。DELTA AVR大于-5%，WBC出现XXXXX，堵孔。
当AVR AVG 结果等于1.75 ±25% (1.21 to 2.19), AVR RM 采用新的计算公式：
AVR RM(new) = 0.8 AVR RM(old) + 0.2 AVR × × R AVG
当CMOS更换新的或者损坏时， AVR RM的系数用1.75来替代，可以通过手工计算，每次RM的值都是1.75的话，可以断定CMOS损坏，厂家一般是换板处理，这里我们不做讨论。
7、WPWV AVG/RM/LTVAR WPWV AVG是wbc脉冲宽度的12次计数周期的连续A/D转换值平均数。WPWV RM是上次样本的A/D转换值，LTVAR是WPWV AVG和WPWV RM的比值。
WPWV AVG 结果大于10% 与WPWV RM的比值WPWV LTVAR = 1.0 堵孔
WPWV AVG结果小于等于 10% ， WPWV LTVAR = 0.0 (结果通过)..
WPWV RM 新的计算公式:
WPWV RM(new) = 0.8 x WPWV RM(old) + 0.2 x WPWV AVG(current).
WPWV AVG 在 410 to 2460 A/D 转换值时 WPWV RM 不采用新的计算公式
当CMOS更换新的或者损坏时，默认的RM值是1400 A/D 转换值.
8、在下列状态下也报XXXXX堵孔：
WBC Target value 0.88 WBC Measured WBC Target value × ≤ ≤ × 1.12
RBC Target value × 0.87≤RBC Measured≤RBC Target value × 1.15
解释如下：
These parameters are 26-percentile values representing pulse width. A 26-percentile value is
determined by the Editor circuit for each one-second count period. Twelve values are
recorded during sample data accumulation, and these twelve values are averaged to produce
the reported measured value. The measured value is then compared to the Target value to
determine if this clog test passes.
9、RBC CV
The CV is calculated using the 12 measured, 26-percentile values determined during sample
data collection. This test fails if the calculated CV is not within the following range:0.5%≤RBC CV≤5.0%
10、WBC/RBC Ratio CVs
The ratio is the ratio of “good” pulses to total pulses. Pulses are processed to determine a
proper size and width. Pulses having the proper size and width are “good” pulses. The editor
receives pulses one-by-one. When it is processing a pulse, it ignores any other pulses that may
come along. “Good” pulses are those that are processed and accepted as good by the editor.
Total pulses are the total pulses counted by the counter circuit, not the total pulses processed
by the editor. A ratio value is determined for each one-second count period.
When sample data accumulation is complete, there are 12 ratio values for WBC and RBC. The
CV of these values is calculated and used for clog detection. The idea behind this criteria is
based on consistency. The ratio of good pulses may vary for a particular sample because of cell
size, shape, elasticity, or concentration. It may even vary with the concentration of other cells
or interfering particles or substances. Once a sample dilution is made however, whatever the
ratio is, it should be consistent through the 12 count periods.
This test fails if the Ratio CV is outside the following limits:
WBC Ratio CV ≤ 8.0%
RBC Ratio CV ≤ 7.5%
11、RBC Ratio Mean
The 12 RBC Ratio values are averaged. If this average is <0.2, this clog test fails.
12、WBC/RBC Voteout
When there is a single aperture count voteout, WBC or RBC, the count from that aperture is
compared to the average count of the other two apertures. If this count is >7.0% higher than
the average of the other two apertures, the voteout test fails.
13、RAV CV
An RBC Aperture Voltage (RAV) reading is taken for each one-second count period. The CV is
calculated for the 12 readings. If the resulting CV is >5.0%, this clog test fails.
14、AVR Measured
The 12 readings for RBC Aperture Voltage (RAV) and WBC Aperture Voltage (WAV) are
averaged. The RAV average is then divided by the WAV average to obtain the Aperture Voltage
Ratio (AVR) Measured. This test fails if:
; this condition generates an RBC failure.AVR (average) > AVR Target × 1.09
; this condition generates a WBC failure.AVR (average) < AVR Target × 0.97
15、WBC/RBC/AVR Target
WBC and RBC Target are target 26-percentile values used for comparison with the WBC and
RBC Measured values during sample analysis. AVR Target is the target Aperture Voltage Ratio
used for comparison with the AVR Measured clog detection test. They are determined by
averaging the value obtained when running several normal samples.
16、RBC Clog Detection Criteria RBC堵孔监测标准
The above tests are used to determine whether a clog has occurred and whether results
should be suppressed with XXXXX or whether the result will be given with a single X flag.
These tests are not performed if:
r A total RBC voteout has occurred.
r Hgb <2.0 g/dL (or Hgb is incomplete and RBC <0.5 x 106 cells/μL).
r RBC count < ≈ 0.20 x 106 cells/μL then RBC Measured is not calculated or used.
r RBC count < ≈ 0.12 x 106 cells/μL then RBC Ratio and RBC Ratio CV are not calculatedor used.
Table 7.1-2 RBC Clog Test Results
Condition Status Effect on Results
No tests fail No clog None
1 test fails Maybe clog X flag
>1 test fails Clog Suppressed
17、WBC Clog Detection Criteria WBC堵孔监测标准
The above tests are used to determine whether a clog has occurred and whether results
should be suppressed with XXXXX or whether the result will be given with a single X flag.
These tests are not performed if:
r A total WBC voteout has occurred.
r Hgb <2.0 g/dL (or Hgb is incomplete and WBC <0.5 x 106 cells/μL).
r WBC count < ≈ 1.7 x 133 cells/μL then WBC Measured is not calculated or used.
r WBC count < ≈ 1.0 x 103 cells/μL then WBC Ratio is not calculated so WBC Ratio CV isnot used.
Table 7.1-3 WBC Clog Test Results
Condition Status Effect on Results
No tests fail No clog None
1 test fails Maybe clog X flag
1 test fails (WBC Ratio is not performed) Clog Suppressed
>1 test fails Clog Suppressed
这些验证都很繁杂，很多单词组合不明就里，除了16、17能看明白外，其余的都模棱两可，其实很清楚只要看明白了就知道怎么回事儿，处理起来也就有了相应的方法和对策了，可惜有很多还是不明白。
下面欢迎大家来讨论。
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